Faculty view

Academic Background

Doctor of Pharmaceutical Sciences (Ph.D.), Chiba University, Japan (April 1991 – March 1994)
Master of Pharmaceutical Sciences, Chiba University, Japan (Oct 1988 – March 1991)
Bachelor of Pharmacy (Honors), University of Dhaka, Bangladesh (June 1982 – Oct 1987)
Higher Secondary Certificate, Notre Dame College (1981)
Secondary School Certificate, Mohammadpur Government High School (1979)

Chowdhury Faiz Hossain is currently Professor and Chairperson of the Department of Pharmacy at East West University. He earned his Bachelor of Pharmacy at Dhaka University in 1987, Master of Pharmaceutical Sciences in 1991, and Doctor of Pharmaceutical Sciences in 1994 at the Chiba University, Japan. In his Ph.D., he discovered a series of novel natural products processing selective monoamine-B inhibitory activity from a fungus, Monascas Lanka.

After completing his doctorate, he accepted a position as a Research Scientist at the Department of Pharmacognosy of the National Institute of Health Science (NIHS), Japan, where he worked for three years. In 1996, he joined as an Assistant Professor of the Pharmacy Department of Dhaka University and was promoted to Associate Professor in 2000. In the same year, he went to the National Center for Natural Products Research (NCNPR) of the University of Mississippi, USA, as Visiting Scientist, where he worked till the end of 2005. He worked there with Frederick A.P. Barnard Distinguished Professor Alice Clark’s research group. Dr. Hossain was instrumental in several federally funded anticancer research projects at the University of Mississippi. He discovered and characterized several series of new anti-tumor agents that selectively block the hypoxia-inducible survival factor known as HIF-1 in breast tumor cells. His research yielded two US patents with several peer-reviewed publications. One of his articles about the discovery of Laurenditerpenol in the Journal of Natural Products was considered the best manuscript published in the year 2004 and received the Jack L. Beal Award by the American Society of Pharmacognosy. Dr. Hossain also discovered a series of dilignans, known as manassantins, from an aquatic plant as the most potent inhibitor of HIF-1α ever known to date.

After returning from the USA, Dr. Hossain joined as Associate Professor and the Head of the Department of Pharmacy at the Manarat International University in March 2006. Soon he was promoted to Professor in June 2006. In January 2009, he joined East West University as Professor. Here he served the university in several different capacities, as Dean of the Faculty of Sciences and Engineering for two and a half years, as Chairperson of the Department of Pharmacy for six years, Member of the Syndicate of the university for two and a half year, members of the Financial Committee of this university for two years and as Member of Academic Council for ten years.

Prof. Hossain received a Certificate of Excellence in recognition of his outstanding academic research contribution in 2009 from East West University. And he also recieved Bangladesh Education Leadership Awards 2019 as Best Professor in Pharmacy Studies by World Education Congress.

KEY ACHIEVEMENTS

Characterized the first and novel marine product from brown algae that inhibit Hypoxia Inducible Factor-1α (HIF-Iα) activation. (U.S. Patent No. 7,375,132)
Purified and characterized the most potent bioactive compounds known to date from an aquatic plant that inhibit HIF-1α activation (U.S. Patent application No. 20090137664).
Isolated the first marine product from a sponge that inhibits multidrug resistance (MDR) efflux pumps in resistant fungi.
Characterized selective anticyanobacterial agents from marine algae.
Identified a series of novel compounds and new selective Monoamine Oxidase B (MAO-B) inhibitors form fungal metabolites.
Received an award of Distinguish Faculty Research from East West University.
Acknowledged as one of the Top Tier Reviewers of the Journal of Natural Products of American Chemical Society.

Professional Experience

Dr. Hossain is an academician and scientist with 24 years of experience in teaching and research. Exceptional track record of productivity. Contributed to various therapeutic projects that delivered successful new drug candidates. Experience in facilitating multiple collaborations to evaluate and implement cutting-edge technologies in Natural Products Drug Discoveries. Conducted more than 18 years of graduate and undergraduate courses at the university level in Medicinal Chemistry, Analytical Chemistry, Pharmacology, Pharmacognosy, etc., and supervised graduate students in their research.

Professor (Jan 15, 2009 ~ date), Department of Pharmacy, East West University
Chairperson (July 11, 2017 ~ date), Department of Pharmacy, East West University
Member of the Finance Committee of EWU (December 24, 2018 – to date)
Chairperson (June 24, 2013 ~July 02, 2015), Department of Pharmacy, East West University
Dean (Aug 19, 2010 ~ Feb 07, 2013), Faculty of Sciences and Engineering, East West University
Member of the Syndicate of EWU (Sept 19, 2010 ~ Feb 07, 2013), East West University
Chairperson (May 11, 2009 ~ Aug 18, 2010), Department of Pharmacy, East West University
Professor and Head (May 06, 2006 ~ Jan 14, 2009), Department of Pharmacy, Manarat Int. University
Dean (March 01, 2008 ~ Jan 14, 2009), Faculty of Science and Technology, Manarat Int. University
Associate Professor and Head (March 06, 2006 ~ May 05, 2006), Department of Pharmacy, Manarat Int. University
Associate Research Scientist (March 01, 2004 ~ Dec 31, 2005), School of Pharmacy, University of Mississippi, USA
Postdoctoral Research Fellow (Oct 16, 2001 ~ Feb 28, 2004), National Center of Natural Product Research, University of Mississippi, USA
Visiting Scientist (Nov 13, 2000 ~ Oct 15, 2001), National Center of Natural Product Research, University of Mississippi, USA
Associate Professor (Nov 07, 2000 ~ Feb 28, 2004) (on leave from Nov 13, 2000), Department of Pharmacy, University of Dhaka
Assistant Professor (Aug 19, 1996 ~ Nov 06, 2000), Department of Pharmacy, University of Dhaka
Fellow of Human Science Foundation (April 01, 1995 ~ Aug 18, 1996), National Institute of Health Sciences, Tokyo, Japan
Fellow of Science and Technology Agency (March 28, 1994 ~ March 27, 1995), National Institute of Health Sciences, Tokyo, Japan

Research Interest

Discovery of drug leads from Natural Products
Development of High-Performance Liquid Chromatographic (HPLC) methods for analysis
Ethno-pharmacology and
Phytochemistry

Selected Publications

“Le Carbone prevents liver damage in non-alcoholic steatohepatitis-hepatocellular carcinoma mouse model via AMPKα-SIRT1 signaling pathway activation”.
Afrin, M.R., Arumugam, S., Pitchaimani, V., Karuppagounder V., Thandavarayan, R.A., Harima, M., Hossain, C.F., Suzuki, K., Sone, H., Matsubayashi, Y., Watanabe, K.
Heliyon (2021), 7: e05888.
“Inhibitory Activity of Extract, Fractions, and Compounds from Zingiber montanum Rhizomes on the Migration of Breast Cancer Cells”.
Al-Amin, M., Eltayeb, N.M., Hossain, C.F., Khairuddean, M., Rahiman, S.S.F.
Planta Medica (2020), 86(06), 387-394.
“Antimicrobial activity of the crude extract, fractions and isolation of zerumbone from the rhizomes of Zingiber roseum”.
Al-Amin, M., Siddiqui, M. A., Ruma, S.A., Mustafa, N., Hossain, C.F.
Journal of Research in Pharmacy (2019), 23(3), 559-566.
“Oral toxicity of arjunolic acid on hematological, biochemical and histopathological investigations in female Sprague Dawley rats”. Aamir, K., Khan, H.U., Hossain, C.F.; Afrin, M.R., Shaik, I., Salleh, N., Giribabu, N., Arya, A.
PeerJ (2019), 7:e8045 (doi: 10.7717/peerj.8045).
“Action of Phytochemicals on Insulin Signaling Pathways Accelerating Glucose Transporter (GLUT4) Protein Translocation”.
Sayem, A.S.M.; Arya, A., Karimian, H., Krishnasamy, N., Hasamnis, A.A., Hossain, C.F.
Molecules (2018), 23: 258 (doi:10.3390/molecules23020258).
“Identification of sildenafil citrate as an adulterant in herbal products using high-performance liquid chromatography with photodiode array detector”,
Al-Amin, M., Sultana, G.N.N., Hossain, C.F.
International Journal of Pharmacy and Pharmaceutical Sciences (2018), 10(9):15-20 (doi:10.22159/ijpps.2018v10i9.26425).
“Can Bio-plastics Replace Non-Biodegradable Plastics?”
Kabir, M. M., Hossain, C.F., Shimizu, K.
Journal of Applied Biotechnology & Bioengineering (2017), 3(4), 1-4 (doi:10.15406 / jabb.2017.03.00074).
“Antinociceptive principle from Curcuma aeruginosa”;
Hossain, C.F., Al-Amina, M., Sayem, A.S.M., Siragee, I.H., Tunan, A.M., Hassan, F., Kabir, M.M., Sultana, G.N.N.;
BMC Complementary and Alternative Medicine (2015), 15:191-197.
“Analgesic principle from Curcuma amada”;
Hossain, C.F., Al-Amina, M., Rahman, K.M.M., Sarker, A., Alam, M.M., Chowdhury, M.H., Khan, S.N., Sultana, G.N.N.; Journal of Ethnopharmacology (2015), 163:273–277.
“Antiulcer principle from Zingiber montanum”;
Al-Amin M., Sultana, G.N., Hossain, C.F.;
Journal of Ethnopharmacology (2012), 141(1):57-60.
“Mitochondrial DNA mutations—candidate biomarkers for breast cancer diagnosis in Bangladesh”;
Sultana, G.N.N., Rahman, A., Shahinuzzaman, A.D.A., Begum, R.A., Hossain, C.F.
Chinese Journal of Cancer (2012), 31(9): 449–454.
“Analgesic and anti-inflamatory activities of Rhynchostylis retusa”;
Al-Amin M., Sultana, G.N., Hossain, C.F.;
Biology and Medicine (2011), 3(5):55-59.
“Saururus cernuus lignans-Potent small molecule inhibitors of Hypoxia-Inducible Factor-1”;
Hossain, C.F.*; Kim, Y.P*.; Baerson, S.R.; Zhang, L.; Bruick, R.K.; Mohammed, K.A.; Agarwal, A.K.; Nagle, D.G.; Zhou, Y.;
Biochemical and Biophysical Research Communications (2005), 333(3):1026 – 1033.
“Molecular-targeted antitumor agents: the Saururus cernuus dineolignans Manassantin B and 4-O-Demethylmanassantin B are potent inhibitors of hypoxia-Activated HIF-1”;
Hossain, C.F.*; Hodges, T.W.*; Kim, Y.P.; Zhou, Y.D.; Nagle, D.G., Journal of Natural Products (2004), 67(5):767 – 771.
“Naturally Occurring Proteasome Inhibitors from Mate Tea (Ilex paraguayensis) Serve as Models for Topical Proteasome Inhibitors”; Arbiser J.L., Li X.C., Hossain, C.F., Nagle, D.G., Smith D.M., Miller P., Govindarajan, B., DiCarlo J., Landis K.R., Journal of Investigative Dermatology (2005), 125:207-212.
“Reversal of fluconazole resistance in multidrug efflux-resistant fungi by the Dysidea arenaria sponge sterol 9a,11a-Epoxycholest-7-ene-3b,5a,6a,19-tetrol-6-Acetate”;
Hossain, C.F.*; Jacob, M.R.*; Mohammed, K.A.; Smillie, T.J.; Clark, A.M.; Walker, L.A.; Nagle, D.G.;
Journal of Natural Products (2003), 66(12):1618 – 1622.
“Laurenditerpenol, a new diterpene from the tropical marine algae Laurencia intricata that Potently inhibits HIF-1 mediated hypoxic signaling in breast tumor cells”;
Mohammed, K.A.; Hossain, C.F.; Zhang, L.; Bruick, R.K.; Zhou, Y.D.; Nagle, D.G.;
Journal of Natural Products (2004), 67(12):2002 – 2007 (This paper reported to be the best and most accessed manuscript published in Journal of Natural Products, a journal of American Chemical Society, in 2004, received the Jack L. Beal Award)
“Monoamine oxidase inhibitor produced by Monascus anka”; Okuyama, E.; Hossain, C.F.; Yamazaki, M. Tennen Yuki Kagobutsu Toronkai Koen Yoshishu (Japanese) (1992), 34:526 – 533.
“Structural elucidation of trichotetronines: polyketides possessing a bicyclo[2.2.2]octane skeleton with a tetronic acid moiety isolated from Trichoderma sp”.
Shirota, O.; Pathak, V.; Hossain, C.F.; Sekita, S.; Takatori, K.; Satake, M.; Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1997), 2961 – 2964.
“A preliminary study on the analgesic activity of Grangea maderaspata”; Ahmed M; Islam M.M; Hossain C.F.; Khan O.F.
Fitoterapia 2001, 72(5), 553 – 4.
“Analgesic principle from the bark of Careya arborea”; Ahmed, M.; Rahman, M.W., Rahman, M.T., Hossain, C.F.;
Pharmazie (2002), 57(10):698 – 701.
“Genipatriol, a new cycloartane triterpene from Genipa spruceana”; Hossain, C.F., Jacob, M.R., Clark, A.M., Walker, L.A.; Nagle, D.G.; Journal of Natural Products (2003), 66(3):398 – 400.
“Carbazole is a naturally occurring inhibitor of angiogenesis and inflammation isolated from antipsoriatic coal tar”;
Arbiser J.L., Govindarajan B., Battle T.E., Lynch R., Frank D.A., Ushio-Fukai M, Perry B.N., Stern D.F., Bowden G.T., Liu A., Klein E., Kolodziejski P.J., Eissa N.T., Hossain C.F., Nagle D.G.;
Journal of Investigative Dermatology (2006), 126(6):1396-402.
“Preliminary pharmacological studies on Piper chaba stem bark”; Rahman, M.T., Shilpi, J.A., Ahmed M., Hossain, C.F.;
Journal of Ethnopharmacology (2005), 99:203 – 209.
“Flavonoid glycosides and cannabinoids from the pollen of Cannabis sativa L”;
Ross, S.A., ElSohly, M.A., Sultana, G.N.N., Mehmedic, Z., Hossain, C.F., Chandra, S.;
Phytochemical Analysis (2005), 16(1):45 – 48.
“Secondary metabolites from plants and marine organisms as selective anti-cyanobacterial agents”; Nagle, D.G.; Sultana, G.N.N.; Schrader, K.K.; Hossain, C.F.; Stanikunaite, R.; Hamann, M.T.; Rajbandari, I.;
Off-Flavors in Aquaculture, ACS Symposium Series 848 (2003), 179 -194. [Book chapter]
“Diuretic activity of Grangea maderaspatana”;
Ahmed, M., Islam, M.M., Hossain, C.F.;
Dhaka Univ. J. Biological Sciences (2001), 10(1):15 – 19.
“Analgesic principle from Abutilon indicum”;
Ahmed, M., Amin, S., Islam, M., Takahashi, M., Okuyama , E., Hossain, C. F.;
Pharmazie (2000), 55(4):314 – 316.
“Study on the separation of water-soluble vitamin B complex using HPL”; Sultana, G.N.N., Kazi, M.A.I., Islam, M.N., Hossain, C.F.;
Dhaka Univ. J. Biological Sciences (2001), 10(1):15 – 19.
“Effect of Glycerolphosphorylcholine (GPC) on Hydrolysis of Phosphatidylcholine by Phospholipid Deacylating Enzymes”;
Sultana, G.N.N., Hossain, C.F., Tamai, Y.;
Bangladesh Journal of Physiology and Pharmacology (1998), 13(2):52 – 54.
“A new series of coumarin derivatives having monoamine oxidase inhibitory activity from Monascus anka”.
Hossain, C.F.; Okuyama, E.; Yamazaki, M.
Chemical & Pharmaceutical Bulletin (1996), 44(8):1535 – 1539.
“Monoamine oxidase inhibitors from a lichen, Solorina crocea (L.) Ach”. Okuyama, E., Hossain, C.F., Yamazaki, M.;
Japanese Journal of Pharmacognosy (1991), 45(2):159 – 62.

“Isolation and purification of arjunolic acid from Terminalia arjuna and evaluation of its toxicological effects in Sprague Dawley rats”. Afrin, M.R., Arya, A., Aamir, K., Khan, H.U., Shaik, I., Salleh, N., Giribabu, N., Sristy F.K., Hossain, C.F.,. Book of Abstracts of PSE-NPS 2020 SUMMIT on Natural Products for Healthy Living, OP(A128), 71. Khulna, Bangladesh.
“Hepatoprotective effect of Basidiomycetes-X against non-alcoholic steatohepatitis in experimental NASH-HCC mice model.” Afrin, M.R., Arumugam, S., Sreedhar R., Karuppagounder, V., Harima, M., Hossain C.F., Watanabe, K. (2020 ). Book of Abstracts of PSE-NPS 2020 SUMMIT on Natural Products for Healthy Living, OP(A129), 71-72. Khulna, Bangladesh.
“Phytochemical screening and evaluation of analgesic activity of cyclo-hexane fraction of Terminalia bellirica in acetic acid induced Swiss albino mice.” Laboni, R.A., Islam, R., Hossain, C.F., Afrin, M.R. (2020). Multidisciplinary International Conference on the Social and Life Sciences, Book of abstract of the Multidisciplinary International Conference on the Social and Life Sciences, 114. Dhaka, Bangladesh.
“Comparative evaluation of analgesic and anti-diabetic activities among different extracts and fractions of Gynura procumbens on experimental mice.” Mahbub, S., Afrin, M.R., Sifat, A., Islam, S., Rizvi, A.M.H., Hossain, C.F. (2020). Book of abstract of the Multidisciplinary International Conference on the Social and Life Sciences, 117. Dhaka, Bangladesh.
“Isolation of FKS1 from the barks of Terminalia arjuna and evaluation of anti-diabetic activity”. Sristy, F.K., Afrin, M.R., Sultana, S., Khondokar, S., Arya, A., Hossain, C.F. (2020). Book of abstract of the Multidisciplinary International Conference on the Social and Life Sciences, 121. Dhaka, Bangladesh.
“Potent New Small Molecule Inhibitors of Hypoxia-Inducible Factor-1 (HIF-1) Activation”. Nagle, D.G., Zhou, Y.D., Mohammed, K.A., Hossain, C.F., Hodges, T.W., Kim, Y.P., Mora, F.D., Baerson, S.R., Agarwal, A.K., Zhang, L., Bruick, R.K., Jones, D.K., AACR-NCI-EORTC International Conference on Molecular Targets and Cancer Therapeutics, Philadelphia, USA 2005, Abstract Book of Abstracts of Poster and Proffered Paper Presentations, 180.
“Molecular-Targeted Antitumor Agents. Two New Classes Of Small Molecules That Potently Inhibit Hypoxia-Inducible Factor-1 Activation In Breast Tumor Cells, Nagle”. D.G., Zhou, Y.D., Mohammed, K.A., Hossain, C.F., Hodges, T.W., Kim, Y.P, Mora, F.D., Baerson, S.R., Agarwal, A.K., Zhang, L., Bruick, R.K., Jones, D.K., The 4th Era of Hope meeting for the Department of Defense (DOD) on Breast Cancer Research Program (BCRP) Pennsylvania, USA 2005
“Marine Natural product as a Source of Agents that Reverse Fluconazole Resistance”. Hossain C.F., Jacob M.R., Smillie T.J., Walker L.A., Clark A.M.; Nagle D.G. International Congress on Natural Product Research, Phoenix, Arizona, USA 2004, Abstract Book, 476.
“Marine Natural product as a Source of Agents that Reverse Fluconazole Resistance”. Hossain C.F., Jacob M.R., Smillie T.J., Walker L.A., Clark A.M.; Nagle D.G. Thad Cochran National Center for Natural Products Research Symposium 2004, Oxford, Mississippi, USA.
“Natural Product Drug Discovery that Target Tumor Hypoxia”. Zhou, Y.D.; Hossain, C.F.; Mohammed, K.A.; Kim, Y. P; Hodges, T.W.; Mora, F.D.; Nagle, D.G. International Congress on Natural Product Research, Phoenix, Arizona, USA 2004, Abstract Book, 476.
“Molecular Targeted Anti-tumor Agents: Laurenditerpenol, A New Diterpene from the Tropical Marine Red Algae Laurencia Intricata Potentially Inhibit HIF-1 Activation”. Mohammed, K.A.; Hossain, C.F.; Zhou, Y.D.; Nagle D. G. International Congress on Natural Product Research, Phoenix, Arizona, USA 2004, Abstract Book, 59.
“Marine Natural Products as Inhibitors of Hypoxia-Induced Gene Expression in Tumors”. Zhou, Y. D., Nagle D.G., Kaleem A.M., and Hossain, C.F. International Symposium on Marine Drugs, Qingdao, China 2004.
“Marine Natural Products as a Source of Agents that Reverse Fluconazole Resistance in Multidrug-Efflux Resistant Fungi”, Nagle D.G., Hossain, C.F., Jacob, M.R., Li, X.C., Agarwal, A.K., Smillie, T.J., Walker, L.A., Clark, A.M., International Symposium on Marine Drugs, Qingdao, China 2004.
“Genipatriol, a New Cycloartane Triterpene From Genipa Spruceana”. Hossain, C.F.; Jacob, M.R.; Clark, A.M.; Walker, L.A; Nagle, D.G. 43rd Annual Meeting of the American Society of Pharmacognosy and 3rd Monroe Wall Symposium Abstract Book, New Jersey, USA 2002, Abstract Book, 202.
“Natural Products as a Source of Agents that Reverse Fluconazole Resistance”. Jacob M.R., Hossain C.F., Agarwal A.K., Nagle D.G., Smillie T.J., Walker L.A., Clark A.M.; Interscience Conference on Antimicrobial Agents and Chemotherapy (ICAAC), USA 2003
“Cyanobacteria-selective Anti-algal Agents for Aquaculture”. Nagle, D.G.; Sultana, G.N.N.; Schrader, K.K.; Hossain, C.F.; Stanikunaite, R.; Hamann, M.T.; Rajbandari, I. 43rd Annual Meeting of the American Society of Pharmacognosy and 3rd Monroe Wall Symposium Abstract Book, New Jersey, USA 2002, Abstract Book, 149 .
“Reversal of Fluconazole Resistance in Candida Species”. Jacob M.R., Hossain C.F., Nagle D.G., Walker L.A., Clark A.M.; Thad Cochran National Center for Natural Products Research Symposium, Oxford, Mississippi, USA 2001.
“Chalcones of Yamahagi (Lespedeza bicolor)”. Hossain, C.F.; Sekita, S.; Satake, M. 116th Annual Meeting of Japanese Pharmaceutical Society Abstract Book , Kanazawa, Japan 1996, Abstract Book, 2, 196.
“Chemical Constituents of Lespedeza bicolor”. Hossain, C.F.; Sekita, S.; Satake, M. 115th Annual Meeting of Japanese Pharmaceutical Society Abstract Book, Sendai, Japan 1995, Abstract Book, 2, 196.
“Chemical Constituents of the Seed of Parkia rouxberghii”. Hossain, C.F.; Sekita, S.; Satake, M. The 4th International Congress on Traditional Asian Medicine Abstracts Book, Tokyo, Japan 1994, Abstract Book, 111.
“New Monoamine Oxidase Inhibitors from Monascus anka”. Hossain, C.F.; Okuyama, E; Yamazaki, M 112th Annual Meeting of Japan Pharmaceutical Society Abstract Book, Kyushu, Japan 1992, Abstract Book, 2, 157.

Patents

“Novel Compounds and Methods for Inhibiting Cellular responses to hypoxia”.
United States Patent # 7375132.
Inventors: Nagle, Dale G, Zhou, Yu-dong, Mohammed, Asjad K, Hossain, Chowdhury Faiz Application Number:11/083371 Publication Date:05/20/2008 Filing Date:03/18/2005
“Saururus cernuus compounds that inhibit cellular responses to hypoxia”.
United States Patent Application # US2009013766A1.
Inventors: Nagle, Dale G., Zhou, Yu-dong, Hossain, Chowdhury Faiz, Hodges, Tyler W. Application Number:12/254463 Publication Date:05/28/2009 Filing Date:10/20/2008

Member of Phytochemical Society of Europe
Member of Bangladesh Pharmaceutical Society

Dr. Chowdhury Faiz Hossain

Faculty

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Academic Background

Short Biography

Professional Experience

Research Interest

Discovery of drug leads from Natural Products

Development of High-Performance Liquid Chromatographic (HPLC) methods for analysis

Ethno-pharmacology and

Phytochemistry

Selected Publications

Awards & Achievements

Teaching Materials

Affiliation Professional Membership

Member of Phytochemical Society of Europe

Member of Bangladesh Pharmaceutical Society

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