Dr. Shamsun Nahar Khan

Professor
Department of Pharmacy

Faculty

Faculty of Sciences and Engineering

Address

A/2, Jahurul Islam Avenue
Jahurul Islam City, Aftabnagar
Dhaka-1212, Bangladesh

Office

Ext: 137 || Room No# 721
shamsun@ewubd.edu

Academic Background

Post doct, in Molecular and Cellular Biology, Harvard University, USA
Ph.D. in Drug Discovery, International Center for Chemical and Biological Sciences, University of Karachi, Pakistan
MS in Pharmaceutical Science, (Jahangirnagar University)
Bachelor of Pharmacy (Honors) (Jahangirnagar University)

Research Interest

Structural Biology
RNA Structure Determination through NMR
Enzyme kinetics
3 Dimensional Quantitative Structure Activity Relationship Studies
Pharmacological research and Chronic toxicological studies
Clinical Microbiology

Selected Publications

International

Analgesic Principle from Curcuma amada, Journal of Ethnopharmacology 2015, Chowdhury Faiz Hossain, Mohammad Al-Amin, Kazi Md. Mahabubur Rahman, Aurin Sarker, Md Mahamudul Alam, Mahamudul Hasan Chowdhury, Shamsun Nahar Khan, Gazi Nurun Nahar Sultana, (2015)
Bitransformation of dehydroabietic acid with microbial cell cultures and α-glucosidase inhibitory activity of resulting metabolites, Journal of Pharmacy and Pharmaceutical Sciences, 6(7): 375-378, (2014)
Potent α-glucosidase inhibitors from the lichen Cladonia species from Sri Lanka, J. Natn. Sci. Foundation Sri Lanka, Veranja Karunaratne1, Vinitha M. Thadhani, Shamsun Nahar Khan and M. Iqbal Choudhary, 42 (1): 95-98, (2014)
Fungal Transformation of Cedryl Acetate and α-Glucosidase Inhibition Assay, Quantum Mechanical Calculations and Molecular Docking Studies of its Metabolites. Sultan S., Choudhary M.I., Khan S.N., Fatima U., Atif M., Ali R.A., Rahman A.U. and Fatmi M.Q. Eurpopean Journal of Medicinal Chemistry, 62(7), 64-70, (2013)
Studies on α-glucosidase Inhibition and Anti-Glycation Potential of Iris loczyi and Iris unguicularis, Mosihuzzaman, M., Naheed, S., Hareem, S., Talib, S., Abbas, G., Khan, S.N., Choudhary, M.I., Sener, B., Tareen, R.B., Israr, M., Life Sciences, 92, 187–192 (2013).
Traditional Medicinal Herbs and Food Plants Have the Potential to Inhibit Key Carbohydrate Hydrolyzing Enzymes In Vitro and Reduce Postprandial Blood Glucose Peaks In Vivo, M. Fawzi Mahomoodally, A. Hussein Subratty, A. Gurib-Fakim, M. Iqbal Choudhary and Nahar Khan, The Scientific World Journal, (2012). USA
Novel-Glucosidase Activator from Pulicaria undulata, Nasir Rasool, Muhammad Abid Rashidb , Saleha Suleman Khand, Zulfiqar Alic , Muhammd Zubaira, Viqar Uddin Ahmadd, Shamsun Nahar Khand, M. Iqbal Choudharyd and Rasool Bakhsh Tareene, Natural Product Communications, (2012). USA
Kaurane-type diterpenoids from Chromoleana odorata, their X-ray diffraction studies and potent alpha-glucosidase inhibition of 16-kauren-19-oic acid, Pascal Wafo Ramsay S.T. Kamdem, Zulfiqar Ali, Shazia Anjum, Afshan Begum, Ogbole O. Oluyemisi, Shamsun N. Khan, Bonaventure T. Ngadjui, Xavier F. Etoa, Muhammed Iqbal Choudhary, Fitoterapia 82, 642-646, (2011). Netherlands
Alpha-glucosidase and tyrosinase inhibitors from fungal hydroxylation of tibolone and hydroxytibolones, M. Iqbal Choudhary, S. Adnan Ali Shaha, Atta-ur-Rahman, Shamsun-Nahar Khan, Mahmud Tareq Hassan Khan, Steroids 75 (2010) 956–966
Duboscic Acid: A Potent alpha-Glucosidase Inhibitor with an Unprecedented Triterpenoidal Carbon Skeleton from Duboscia macrocarpa, Pascal Wafo, Ramsay S. T. Kamdem, Zulfiqar Ali, Shazia Anjum, Shamsun Nahar Khan, Afshan Begum, Karsten Krohn, Berhanu M. Abegaz,| Bonaventure T. Ngadjui, and Muhammad Iqbal Choudhary, Orgainc Letters, vol.12, No. 24, 5760-5763, (2010). USA

Alpha-glucosidase and tyrosinase inhibitors from fungal hydroxylation of tibolone and hydroxytibolones, M. Iqbal Choudhary, S. Adnan Ali Shah, Atta-ur-Rahmana, Shamsun Nahar Khan, Mahmud Tareq Hassan Khan, Steroids, 75, 956–966, (2010). USA
Alphaglucosidase Inhibitors from Fungal Hydroxylation of Tibolone and Hydroxytibolone, Viqar Uddin Ahmed, Nasir Rasool, M. Iqbal Choudhary, Atta-ur –Rahman, Syed Adnan Ali Shah, Shamsun Nahar Khan, United States, Patent Publication: US 2009/0137542 A1. (2009) USA

α-Glucosidase Inhibitory Activity of new Triterpenoids from Cichorium inbytus, Atta-ur-Rahman, Seema Zareen, M.Iqbal Choudhary, M. Nadeem Akhtar and Shamsun Nahar Khan, Journal of Natural Product, Nat. Prod., 71, 910–913, (2008). USA
Antioxidant Activity of the Crude Extract of the Fruits of Pycnanthus angolensis and Alpha-Glucosidase Inhibitory Activity of its Constituents, Alembert T. Tchinda*, Marguerite H. Tchuendem, Shamsun N. Khan, Iman Omar, François Ngandeu, Pepin, E.A. Nkeng, Iqbal M. Choudhary, Pharmacologyonline 1 : 422- (2008).
Synthesis, Spectroscopy and Biological Properties of Vanadium (IV)-Hydrazide Complexes, Uzma Ashiqi, Rifat Ara, Mohammad Mahroof Tahir, Zahida T. Maqsood, Khalid M. Khan, Shamsun N. Khan, Hina Siddiqui and Muhammad I Choudhary, Chemistray and Biodiversity, 5, (2008).
Bioactive aristolactams from Piper umbellatum, Turibio Kuiate Tabopda, Joseph Ngoupayo, Jiawei Liu, Anne-Claire Mitaine-Offer, Sheraz A. Khan Tanoli, Shamsun Nahar Khan, Muhammad Shaiq Ali, Bonaventure Tchaleu Ngadjui, Etienne Tsamo, Marie-Aleth Lacaille-Dubois, Bang Luu, Phytochemistry 69, 1726–1731, (2008), UK
Microbial Transformation of Hydroxyprogesterone and Alpha-Glucosidase Inhibition Activity of its Metabolites, Iqbal Choudhary, M. Nasir, S. N. Khan, M. Atif, R. A. Ali, S. M. Khalil, Atta-ur-Rahman, Zeitschrift für Naturforschung, 62b, 593-599, (2007). Germany
α-Glucosidase Inhibitory Constituents from Stem Bark of Terminalia superba (Combretaceae), Jean Duplex Wansi, Marie-Christine Lallemand, David Daco Chiozem, Flavien Aristide A. Toze a, Luc Meva’a Mbaze, Shamsun Nahar khan, Muhammad Choudhary Iqbal, Francois Tillequin, Jean Wandji, Zacharias Tanee Fomum, Phytochemistry, 68, 2096–2100, (2007). UK
α-Glucosidase Inhibitory Pentacyclic Triterpenes from the Stem Bark of Fagara tessmanni (Rutaceae), Luc Meva’a Mbaze, Herve Martial P. Poumale, Jean Duplex Wansi, Jean Alexandre Lado, Shamsun Nahar Khan, Muhammad Choudhary Iqbal, Bonaventure Tchaleu Ngadjui, Hartmut Laatsch, Phytochemistry, 68, 591-595, (2007). UK
Science and the Interface of Chemistry and Biology: Discoveries Inhibitors and Antiglycation Agents, Atta-ur-Rahman, M. I. Choudhary, F. Z. Basha, G. Abbas, S. N. Khan Pure and Applied Chemistry, 79(12) 2263-2268 (2007).
New Treatment of Diabetes Mellitus, Viqar Uddin Ahmed, Nasir Rasool, M. Iqbal Choudhary, Shamsun Nahar Khan, United States, Patent Publication: US 2007/0287674 A1, (2007). USA
α-Glucosidase Inhibitors from Millettia conraui, Alembert Tiabou Tchinda, Shamsun Nahar Khan, Victorine Fuendjiep, François Ngandeu, Annie Ngono Ngane, and Muhammad Iqbal Choudhary, Pharm. Bull., 55 (9), 1402-1403. (2007). Japan
A new Steroid and Glucosidase Inhibitors from Anthocleista schweinfurthii, R.N. Mbouangoueere, P. Tane, D. Ngamga, N. Khan, M.I. Coudhary and B.T. Ngadjui, Research Journal of Medicinal Plant 1(3), 106-111, 2007.
Alpha-Glucosidase Inhibitory Constituents from the Stem Bark of Harungana madagascariensis, Simeon F. Kouam, Shamsun Nahar Khan, Karsten Krohn, Bonaventure T. Ngadjui, Deccaux G. W. F. Kapche, Diane Yapna, Seema Zareem, Amal M. Y. Moustafa, and M. Iqbal Choudhary, Journal of Natural Product Chemistry, 69, 229-233. (2006) USA
New Antibacterial and α-Glucosidase Inhibitors from Myrtus communis, Farzana Shaheen, Manzoor Ahmad, Shamsun Nahar Khan, Syeda Samreen Hussain, Shazia Anjum, Bahodir Tashkhodjaev, Kambarali Turgunov, Mukhlis N. Sultankhodzhaev, Muhammad Iqbal Choudhary, and Atta-ur-Rahman, Eur. J. Org. Chem., 2371, (2006). USA
a-Glucosidase Inhibitory and Antioxidant Acridone Alkaloids from the Stem Bark of Oriciopsis glaberrima E(Rutaceae), Jean Duplex Wansi, Jean Wandji, Luc Meva’a, Alain Francois Kamdem Waffo, Rosa Ranjit, Shamsun Nahar Khan, Azaz Asma, Choudhary Muhammad Iqbal, Marrie-Christane Lallemand, Francois Tilequin and Zacharias Fomum Tanee, Chem Pharm Bull. 54 (3), 292-296, (2006). Japan
Synthesis and Biological Activities of Benzothiazepine Derivatives and of their intermediate Chalcones as Antioxidant, Cholinesterase, Urease and α-Glucosidase Inhibitors, Farzana Latif Ansari, Sumaira Umbreen, Latiff Hussain, Talat Makhmoor, Sarfraz A. Nawaz, M. Arif Lodhi, Shamsun Nahar Khan, Farzana Shaheen, M. Iqbal Choudhary and Atta-ur-Rahman, Chemistry & Biodiversity, 2, 487-496, (2005). Switzerland
a-Glucosidase Inhibiting and Chymotrypsin Inhibiting Lignans from Commiphora Mukul, Muhammad Athar Abbasi, Viqar Uddin Ahmad, Muhammad Zubair, Shamsun Nahar Khan and M. Iqbal Choudhary, Pakistan Acad. Sci. 42(1): 23-26, (2005). Pakistan
Anew a- Glucosidase Inhibiting Dithiadiazetidin Derivative from Symplocos racemosa, Muhammad Athar Abbasi Viqar Uddin Ahmad, Muhammad Zubair, Muhammad Abid Rashid, Shamsun Nahar Khan, Iqbal Choudhary and Klaus–peter Zeller Heterocycles, 65, No: 8, (2005). Japan
Spectral assignments and Reference Data, Structure determination of bioactive galloyl derivatives by NMR spectroscopy, Viqar Uddin Ahmad, Muhammad Zubair, Muhammad Abid Rashid, Nasir Rasool, Shamsun Nahar Khan and M. Iqbal Choudhary and Farzana Kousar, Magnetic Resonance in Chemistry, 43, 486-488, (2005). USA
α-Glucosidase Inhibitory Constituents from Duranta Repens, Kiran Iqbal, Abdul Malik, Naveen Mukhtar Itrat Anis, Shamsun Nahar Khan, and Muhammad Iqbal Choudhary, Pharm. Bull, 52 (7) 785-789, (2004). Japan
Pakisolides A and B, Novel Enzyme Inhibitory and Antioxidant Dimeric 4-(Glucosyloxy) Benzoates from Berchemia Pakistanica, Naveen Mukhatar, Abdul Malik, Naheed Riaz, Kiran Iqbal, Rasool BakhshTareen, Shamsun Nahar Khan, Sarfraz Ahmad Nawaz, Juveria Siddiqui and M. Iqbal Choudhary, Helvetica Chemica Acta, 87, 416-424, (2004). Switzerland
Berchemins A and B: Novel Enzyme–Inhibiting Dimeric Lignan Glycosides from Berchemia Pakistanica, Naveen Mukhatar, Abdul Malik, Kiran Iqbal, Rasool BakhshTareen, Shamsun Nahar Khan Sarfraz Ahmad Nawaz, and M. Iqbal Choudhary, Helvetica Chemica Acta, 87, 2050-2056, (2004). Switzerland
Brevipsidone, a New Depsidone and Other α-Glucosidase Inhibitors from Garcinia brevipedicellata (Clusiaceae), Joseph Ngoupayoa, Diderot T. Noungouea, Bruno N. Lentaa, Turibio K. Tabopdaa, Shamsun N. Khan, Silvère Ngouelaa, Mohammad A. Shaiqb and Etienne Tsamoa, Natural Product Communications, 2 (11), 1141-1144.
Fungal Transformation and α-Glucosidase Inhibition Activity of Cedryl Acetate, M. Iqbal Choudhary, Sadia Sultan, Shamsun Nahar Khan, Muhammad Qaiser Fatmi, Urooj Fatima, Rahat Azhar Ali, Muhammad Atif and AttaurRahman, Chemistry and Biodiversity, accepted. SWITZERLAND.

Patent Title: Method of producing tibolone metabolites by fermentation with Rhizopus stolonifer, Inventors: Attaur Rahman, Mohammed Iqbal Choudhary, Syed Adnan Ali Shah, Shamsun Nahar Khan, Assignees: International Center for Chemical Sciences  IPC8 Class: AC12P3300FI  USPC Class: 435 52  Class name: Preparing compound containing a cyclopentanohydrophenanthrene nucleus; nor-, homo-, or D-ring lactone derivatives thereof  Publication date: 05/26/2011, US Patent application number: 20110124041, (2011). USA
Patent Title: Method of producing tibolone metabolites by fermentation with Fusarium lini, Inventors: Attaur Rahman, Mohammed Iqbal Choudhary, Syed Adnan Ali Shah, Shamsun Nahar Khan, Assignees: International Center for Chemical Sciences  IPC8 Class: AC12P3300FI  USPC Class: 435 52  Class name: Preparing compound containing a cyclopentanohydrophenanthrene nucleus; nor-, homo-, or D-ring lactone derivatives thereof  Publication date: 05/26/2011 US Patent application number: 20110124042, (2011). USA
Patent Title: Method of producing tibolone metabolites by fermentation with Gibberella fujikuroi, Inventors: Atta-ur-Rahman, Mohammad Iqbal Choudhary Syed Adnan Ali Shah, Shamsun Nahar Khan, International Center for Chemical Sciences, IPC8 Class: AC12P3312FI  USPC Class: 435 54  Class name: Acting on D-ring  Publication date: 05/26/2011, US Patent application number: 20110124043 (2011), USA.
Patent Title: Alpha-glucosidase inhibitors from fungal hydroxylation of Tibolone and hydroxytibolones, Inventors: Atta-ur-Rahman, Muhammed Iqbal Choudhary, Syed Adnan Ali Shah, Shamsun Nahar Khan IPC8 Class: AC12P3306FI, USPC Class: 514178. US Patent application number: 20090137542, (2009).USA
Patent Title: New alpha-glucosidase inhibitors and antibacterial compounds from Myrtus communis L., Inventors: Attaur Rahman, Mohammad Iqbal Choudhary, Farzana Shaheen, Manzoor Ahmad, Shamsun Nahar Khan, Shazia Anjum, Assignees: International Center for Chemical Sciences, IPC8 Class: AC07D49304FI, USPC Class: 549382
Class name: Pentacyclo ring system having the hetero ring as one of the cyclos
Publication date: 10/30/2008, US Patent application number: 20080269510, (2008). USA
Patent Title: β-amyrin acetate for treatment of diabetes mellitus, Inventors: Wijayabandara, Mirihanage Don Jayantha; Khan, Shamsun Nahar Khan; Choudhary, Muhammad Iqbal, Publication date: 05/01/2008, US Patent application number: US2006-553465, (2008). USA
Patent Title: Patent application title: Novel alpha glucosidase activator, pulicarside 1, Inventors: Viqar Uddin Ahmad, Muhammad Iqal Choudhary, Nasir Khan, Shamsun Nahar Khan, Assignees: HEJ Research Institute, IPC8 Class: AA61K317028FI, USPC Class: 514 27, Class name: Oxygen of the saccharide radical bonded directly to a nonsaccharide hetero ring or a polycyclo ring system which contains a nonsaccharide hetero ring, Publication date: 11/06/2008
Patent application number: 20080274987, (2008), USA

“TWAS Young Affiliate Fellowship 2014, World Academy of Sciences (TWAS), Trieste, Italy.
First Chemistry Prize: “Atta-ur-Rahman Prize in Chemistry” Sept, 2012 by Third world Academy of Sciences (TWAS), Trieste, Italy.
TWAS 2011 Prize to Young Scientists from Bangladesh Award 2011, Bangladesh Academy of Science -Third world Academy of Sciences (TWAS), Trieste, Itally.
Global Young Academy of Sciences 2013, Germany
Award of “MERIT SCHOALRSHIP PROGRAM FOR HIGH TECHNOLOGY” Sept, 2010, Islamic Development Bank (IDB), Jeddah, Saudi Arabia
Award of “Excellence in Research and Teaching”, 14 Foundation Day, East West University, (2009).

Bioassay Models for Antidiabetic Activity of Natural Products, M. Iqbal Choudhary and Shamsun Nahar Khan, International Center for Chemical Sciences, H. E. J. Research Institute of Chemistry, University of Karachi, Karachi, Pakistan (published by International Center for Science and High Technology, United Nations Industrial Development Organization, Trieste, Itally).